Odontogenic cysts are closed sacs, and have a distinct membrane derived from rests of odontogenic epithelium. Paradental cyst is an inclusion cyst of the junctionalsulcular epithelium of the gingiva. Also called as odontogenic ghost cell cyst or gorlin cyst. The aneurysmal bone cyst 1 is an even rarer cyst, which occurs in a similar age group and has a similar site distribution to the solitary bone cyst although enlargement of the mandible is a more. A dentigerous cyst encloses the crown of an unerupted tooth by expansion of its follicle and is attached to the neck of the tooth. This study was aimed to evaluate and compare the density of mast cells in dentigerous cyst dc and keratocystic odontogenic tumor kcot regarding their different clinical behavior. The proliferative activity in the okc was studied by various investigators and it was compared to other odontogenic cysts and tumours. It appears mostly in young patients and females, the maxillary. Revisited swagatikapanda, 1 sujitranjansahoo, 1 gunjansrivastav, 2 subratpadhiary, 3 kanikasinghdhull, 4 andsoniaaggarwal 5 department of oral pathology and microbiology, institute of dental sciences, kalinga nagar, bhubaneswar, india. This article aims to discuss the clinical features, radiological assessment, histopathology and management of a variety of odontogenic cysts. Because cystic sp aces within the jaws have special characteristics, they require a more precise definition.
Expression of ck14 and vimentin in adenomatoid odontogenic. The cyst encloses the crown of an unerupted tooth by the expansion of its follicle due to a collection of cystic fluid. Expression of ck14 and vimentin in adenomatoid odontogenic tumor and dentigerous cyst. Review of the molecular pathogenesis of the odontogenic keratocyst. Odontogenic cysts of upper jaw an analysis allied academies. Cysts are frequent lesions occurring in the oral cavity and are of much significance because they may be destructive and cause significant signs. The pathogenesis is similar to a dentigerous cyst in that the epithelium. Role of cytokeratin7 in the pathogenesis of odontogenic cysts an. Has many features of odontogenic tumor, therefore it is placed in the category of tumors in the latest who classification of odontogenic cysts and tumors. This article attempts to analyze all cases of odontogenic cysts involving upper jaw. Odontogenic cysts, tumors, and related jaw lesions preceptor. C botryoid odontogenic cyst gingival cysts c gingival cysts of adults c gingival of infants alveolar cyst glandular odontogenic cyst calcifying odontogenic cyst orthokeratinised odontogenic cyst table 1 figure 1 radicular cyst at the apex of a dead tooth with necrotic pulp.
The authors conducted a search in english literature using the following keywords. Role of cytokeratin7 in the pathogenesis of odontogenic. Comparison of components of odontogenic cyst fluids. Dec 11, 2018 treatment options for jaw tumors and cysts vary, depending on the type of growth or lesion you have, the stage of growth, and your symptoms. Adenomatoid odontogenic tumor aot is a rare odontogenic tumor which is often misdiagnosed as odontogenic cyst. The pathogenesis of the three common forms of odontogenic cyst is discussed. Ptch expression in odontogenic cysts, a cause of pathogenesis or reason for clinical complication.
Odontogenic carcinoma is rare group of malignant epithelial odontogenic neoplasms with characteristic clinical behavior and histological features, which requires an aggressive surgical approach. Jaw tumors and cysts symptoms and causes mayo clinic. Cytokeratins are integral components in tooth development and are expressed across the odontogenic tissues in physiological and pathological states. Pdf ptch expression in odontogenic cysts, a cause of. Cysts and odontogenic neoplasms 160 jaw cysts general features of jaw cysts to physicians, the term cyst means, simply, a space. Review article pathogenesis and nomenclature of odontogenic. Cyst formation, like the development of neoplasms, involves a dysregulation of the balance between cell proliferation and cell death. Oct 27, 2017 the aneurysmal bone cyst 1 is an even rarer cyst, which occurs in a similar age group and has a similar site distribution to the solitary bone cyst although enlargement of the mandible is a more.
The dentigerous cyst arises from pooling of inflammatory exudate, which is derived from the obstructed follicular veins of an unerupted tooth and accumulates. Odontogenic keratocyst an overview sciencedirect topics. Odontogenic cysts and odontogenic tumors in a large rural. Glandular odontogenic cyst sialo odontogenic cyst very rare pathogenesis of odontogenic cysts cyst formation in the jaws requires three elements. Odontogenic and non odontogenic tumors of the jaws are a relatively rare and heterogeneous group of benign and malignant neoplasms, hamartomas, and other bonerelated lesions that demonstrate great variability in etiology, biologic behavior, and clinical significance. The cyst is attached to the apex and is composed of an in. Inflammation progressing from root apex of carious or necrotic deciduous tooth brings about development of dentigerous cyst around underlying, unerupted permanent tooth. Longstanding chronic inflammation in a periapical granuloma secondary to pulpal necrosis stimulates epithelial proliferation. Mouth, jaw and face oral and maxillofacial surgeons can treat your jaw tumor or cyst usually by surgery, or in some cases, by medical therapy or a combination of surgery and medical therapy. Introduction a cyst is an epithelium lined sac containing fluid or semifluid material the epithelial cells first proliferate and later undergo degeneration and liquefaction grow by.
It also highlights the reclassification of odontogenic keratocysts to keratocystic odontogenic tumours. Odontogenic and nonodontogenic tumors of the jaws are a relatively rare and heterogeneous group of benign and malignant neoplasms, hamartomas, and other bonerelated lesions that demonstrate great variability in etiology, biologic behavior, and clinical significance. The dentigerous cysts are odontogenic cysts that are most frequently found in individuals in the age group between 20 and 40 years. Cyst development requires the presence of epithelium in deep tissues and a proliferative stimulus. It most often affects the posterior mandible and most commonly presents in the third decade of life.
Odontogenic cysts ioannis chatzistefanou, vassilios kogias and. Pathogenesis and nomenclature of odontogenic carcinomas. Keratocysts have characteristic locations, the ramus of the mandible, the canine region in the. It is caused by alteration of reduced enamel epithelium after the completion of amelogenesis, which results in fluid accumulation between epithelium and tooth crown. The possible role of mast cells in the odontogenic cysts. It is concluded that the dental cyst arises from proliferation of the epithelial rests of malassez in a focus of inflammation stimulated by pulpal necrosis of the associated tootli. Probable growth factors mitogen involved in the pathogenesis of radicular. Radiology of cysts of the jaws columbia university. Pathogenesis of dental cysts international medical college. These are individual lesions which arise from the same odontogenic apparatus but with varying pathogenesis. On radiographs, the calcifying odontogenic cyst appears as a unilocular radiolucency dark area.
Inflammatory odontogenic cysts 1 radicular cyst see od1 notes cyst at apex or around root of a nonvital tooth. Because the lesion sometimes appears as a solid noncystic lesion, referred to as odontogenic ghost cell tumor, it is no longer classified as one of the odontogenic cysts. The possible role of mast cells in the odontogenic cyst s pathogenesis. Teeth develop from budlike invagination of ectodermal lining of primitive oral cavity epithelium. Odontogenic cysts are distinct entities and quite a common occurrence in the jaw bones. It is concluded that the dental cyst arises from proliferation of the epithelial rests of malassez in a focus of inflammation stimulated by pulpal necrosis of. Chapter 21 odontogenic and non odontogenic tumors of the jaws introduction. Odontogenic keratocyst and keratocystic odontogenic tumour. The exact pathogenesis of dentigerous cyst is unknown. Calcifying odotogenic cyst is a benign odontogenic tumor of cystic type most likely to affect the anterior areas of the jaws.
It is concluded that the dental cyst arises from proliferation of the epithelial rests of malassez in a focus of inflammation stimulated by pulpal necrosis of the associated tooth. The dentigerous cyst arises from pooling of inflammatory exudate, which is derived frotn the obstructed follicular veins of an unerupted tooth and accumulates. Odontogenic cysts and tumors ppt linkedin slideshare. Dec 22, 2016 cysts are frequent lesions occurring in the oral cavity and are of much significance because they may be destructive and cause significant signs and symptoms. The glandular odontogenic cyst is usually asymptomatic and involves the mandible more often than the maxilla. It enlarges by unicentric expansion from the hydrostatic pressure of its contents. It is most common in people in their second to third decades but can be seen at almost any age.
Chapter 21 odontogenic and nonodontogenic tumors of the jaws introduction. Adenomatoid odontogenic tumor is a hamartomous benign neoplasia of odontogenic origin. This is an open access article distributed under the terms of the creative commons attributionnoncommercialsharealike 3. Three major types of odontogenic cyst are recognizable on the basis of their epithelial derivation, dental relation.
The pathogenesis of dental cysts can usually be described as a consequence of and as originating from remnants of the complicated process of embryonal tooth and jaw development. The following classification system is a modification of the world health organization. A dentigerous cyst is formed by the hydrostatic force exerted by the accumulation of fluid between reduced enamel epithelium and the tooth crown of unerupted teeth,5. An odontogenic keratocyst is a rare and benign but locally aggressive developmental cyst. Research article the possible role of mast cells in the. Induced proliferation of epithelial cell rests rests of serres or malassez in the jaw region plays an important role in the pathogenesis of odontogenic cysts. Comparable changes do not occur in any other region of the body. The most common developmental odontogenic cyst is the dentigerous cyst.
Odontogenic cyst are a group of jaw cysts that are formed from tissues involved in odontogenesis tooth development. Mcqs on odontogenic cysts and tumors oral pathology part 2. The glandular odontogenic cyst goc is an uncommon cyst of the jaws, locally aggressive and with recurring potential 1 kramer irh, pindborg jj, shear m, eds. Review article pathogenesis and nomenclature of odontogenic carcinomas.
The calcifying odontogenic cyst coc is an uncommon odontogenic lesion with a somewhat wide spectrum of histologic features. Odontogenesis, odontogenic cysts, and odontogenic tumors. A keratocystic odontogenic tumor kot formerly known as an odontogenic keratocyst is a benign cystic tumor of dental origin that probably arises from primitive dental lamina, most commonly occurs in the posterior mandible, and almost certainly represents the lesion that used to be known as a primordial cyst. For each tooth, odontogenesis table 3 begins with the formation. Recently, mast cells were recognized in the pathogenesis of more aggressive pathologic lesions. Factors such as inflammation or trauma stimulate epithelial rests to proliferate sealing off the. Pdf the purpose of this study was to determine the prevalence of odontogenic cysts at.